Industrial society has introduced or increased human exposure to thousands of chemicals in the environment. Examples are inorganic materials such as lead, mercury, arsenic, cadmium, and asbestos, and organic substances such as polychlorinated biphenyls (PCBs), vinyl chloride, and the pesticide DDT. Of particular concern is the delayed potential for these chemicals to produce cancer, as in the cases of lung cancer and mesothelioma caused by asbestos, liver cancer caused by vinyl chloride, and leukemia caused by benzene. Minamata disease, caused by food contaminated with mercury, and Yusho disease, from food contaminated with chlorinated furans, are examples of acute toxic illnesses occurring in nonoccupational settings.
The full toxic potential of most environmental chemicals has not been completely tested. The extent and frequency of an illness are related to the dose of toxin, in degrees depending on the toxin. For chronic or delayed effects such as cancer or adverse reproductive effects, no “safe” dose threshold may exist below which disease is not produced. Thus, the cancer-producing potential of ubiquitous environmental contaminants such as DDT or the PCBs remains undefined.
The full toxic potential of most environmental chemicals has not been completely tested. The extent and frequency of an illness are related to the dose of toxin, in degrees depending on the toxin. For chronic or delayed effects such as cancer or adverse reproductive effects, no “safe” dose threshold may exist below which disease is not produced. Thus, the cancer-producing potential of ubiquitous environmental contaminants such as DDT or the PCBs remains undefined.
