Environmental diseases are caused by chemical agents, radiation, and physical hazards. The effects of exposure, in both natural and work settings, are greatly influenced by the exposure routes: primarily air pollution and water pollution, contaminated food, and direct contact with toxins. Synergistic effects—two or more toxic exposures acting together—are also important, as illustrated by the greatly increased risk of lung cancer in asbestos workers who smoke cigarettes. The potential interaction of multiple hazardous chemicals at toxic waste dumps poses a current public health problem that is of unknown dimensions.